IMMUNOBIOLOGY Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells
نویسندگان
چکیده
1Life and Medical Sciences (LIMES) Institute, Laboratory for Molecular Immunology, University of Bonn, Bonn, Germany; 2Institute of Immunology, Hannover Medical School, Hannover, Germany; 3Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; 4Institute for Molecular Cardiovascular Research (IMCAR), Rheinisch-Westfaelische Technische Hochschule (RWTH) University Aachen, Aachen, Germany; and 5Max-Planck-Institute for Biochemistry, Martinsried, Germany
منابع مشابه
Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
Adhesion and motility of mammalian leukocytes are essential requirements for innate and adaptive immune defense mechanisms. We show here that the guanine nucleotide exchange factor cytohesin-1, which had previously been demonstrated to be an important component of beta-2 integrin activation in lymphocytes, regulates the activation of the small GTPase RhoA in primary dendritic cells (DCs). Cytoh...
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